Question: How to ensure that dsolve works

Hi i was trying to numerically integrate my freinds model with dsolve, and i am sure that I have put all the right components in the command as described in the help page, but it doesn't work. (Here is a worksheet with the model Lindas_signal_transduction_model.mw )

What is the problem with the way I have called the function?
Does anyone have a mental checklist that they use for dsolve commands? because I often struggle with making them work.

 

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