Question: How to change datatype of multiple columns in dataframe at once?

I was working with a Dataframe when I wanted to change the datatype of multiple columns at the same time as this is quite a large dataframe. I found in the helpfile that I can change datatype by the following command: 

SubsDatatype(Data, plts, float) which then change the datatype of "plts" into float. I had hoped that using multiple columns in the command would work in this way: SubsDatatype(Data, [plts, act], float)  but apparently not. Is there a way to do this or do I have to do it column by column?

Additionally I have another question about dataframes. I would like to replace "0" in the dataframe by a "blank" as you can do in excel. How do you do this in a dataframe?

Thanks in advance for any help given!