Question: Optimize Parameter ODE (Ref: Robert Lopez)

Dyson_Mclean_V3.mw

Dyson_Mclean_V5.mw

Hi All,

I have a question that I see has been seldom discussed except certain posts by Mr. Lopez. This concerns the estimation of optimum parameters of the solution of a system of differential equations to fit experimental data. I referred to the Maple document provided by Mr. Lopez on the Maplesoft website.

Link: http://www.maplesoft.com/applications/view.aspx?SID=1667

I have a system of DE with 5 variables with actually 8 parameters reducible to 2 parameters. I set up my worksheet as suggested in the document by Mr. Lopez. However I am unable to get a sensible solution.When I solve the system with manually input parameters the solution makes sense.When I try to use NLPSolve ith the same parameters as initial points nothing happens.

The uploaded files, Dyson_McLean_V3 and Dyson_McLean_V5 are the two cases. The first one is with the manual input and the second is with the attempt to optmise the parameters.

Any help is sincerely appreciated.

Thank you,

Regards